Reducing chronic inflammation in older people living with HIV
Official title: Targeting the transcriptionally-active reservoir to reduce chronic inflammation in aged people with HIV
Funded at J. David Gladstone Institutes · NIH-11043399 · Data updated 2026-11-12
This study is looking at how the hidden HIV in older adults affects their health and causes ongoing inflammation, and it aims to understand the differences between men and women aged 65 and up to find better ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $891,217 |
| NIH project number | 5R01AI183286-02 |
| Project ID | NIH-11043399 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are living with HIV, particularly those experiencing chronic inflammation.
✕Less likely to help
Patients who are younger than 65 or those without HIV may not benefit from this research.
What this research studies
This research investigates how the HIV reservoir, which remains active despite treatment, contributes to chronic inflammation in older adults with HIV. The study focuses on individuals aged 65 and older, examining the differences in immune responses between men and women in this age group. By utilizing advanced single-cell sequencing technology, researchers aim to characterize the active HIV reservoir and explore methods to inhibit its expression, potentially leading to improved health outcomes for elderly patients. Participants will include both those with controlled HIV and those with ongoing viral activity.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve the overall health of older adults living with HIV.
How similar studies have gone: Other research has shown promise in targeting HIV reservoirs and reducing inflammation, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Roan, Nadia R — J. David Gladstone Institutes
- Study coordinator: Roan, Nadia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.