Reducing cardiovascular and immune issues after spinal cord injury
Multipronged approach to diminish sympathetic hyperreflexia and ensuing cardiovascular and immune dysfunction after spinal cord injury
This study is looking at how spinal cord injuries can impact heart and immune system health, and it's testing a new treatment that combines a special peptide with a medication to help improve nerve function and overall well-being for people with these injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Drexel University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11075273 on NIH RePORTER |
What this research studies
This research investigates how spinal cord injury (SCI) affects the sympathetic nervous system, leading to cardiovascular and immune dysfunction. Using a rodent model, the study aims to test a treatment that combines a specific peptide with a drug to improve nerve function and reduce these complications. By targeting the underlying causes of sympathetic hyperreflexia, the research seeks to restore normal sympathetic activity and enhance overall health in individuals with SCI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a spinal cord injury and are facing cardiovascular or immune-related complications.
Not a fit: Patients who have not sustained a spinal cord injury or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve cardiovascular health and reduce infection risks for patients with spinal cord injuries.
How similar studies have performed: Previous research has shown promise in addressing similar issues related to sympathetic nervous system dysfunction after spinal cord injury, indicating potential for success with this approach.
Where this research is happening
Philadelphia, United States
- Drexel University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Tom, Veronica Jean — Drexel University
- Study coordinator: Tom, Veronica Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.