Reducing breast cancer risk by targeting a specific pathway related to breast density
Targeting RANK Pathway in Mammographic Density and Primary Breast Cancer Prevention
['FUNDING_R37'] · WASHINGTON UNIVERSITY · NIH-10799151
This study is looking at how a medication called denosumab might help lower breast density and reduce the risk of breast cancer in women who are at high risk and still have their periods.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10799151 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the RANK pathway in breast density and its connection to breast cancer risk. It aims to conduct a randomized clinical trial to assess the effects of a medication called denosumab, which inhibits RANK ligand, on reducing mammographic density in high-risk premenopausal women. By targeting this pathway, the study seeks to provide a new approach to breast cancer prevention, particularly for those with dense breast tissue. Participants will be monitored for changes in breast density and potential reductions in cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are premenopausal women with dense breasts who are at high risk for breast cancer.
Not a fit: Patients who do not have dense breasts or are not at high risk for breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for breast cancer in women with dense breasts.
How similar studies have performed: While the approach of targeting the RANK pathway is promising, definitive clinical trial data on its effectiveness in reducing breast density and preventing breast cancer are currently lacking.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TORIOLA, ADETUNJI T — WASHINGTON UNIVERSITY
- Study coordinator: TORIOLA, ADETUNJI T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Prevention, Breast Cancer Risk Factor