Reducing artery narrowing after vascular surgery
Official title: Targeted suppression of ALDH1A3 for endothelial beneficial management of restenosis after vascular surgery
Funded at University of Virginia · NIH-11177762 · Data updated 2026-11-12
This study is looking at how lowering a certain protein called ALDH1A3 might help your blood vessels heal better after procedures like angioplasty, which could lead to fewer complications and better recovery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | August 26, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $719,626 |
| NIH project number | 5R01HL171140-02 |
| Project ID | NIH-11177762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals scheduled for angioplasty or similar vascular procedures.
✕Less likely to help
Patients who have not undergone vascular surgery or have conditions unrelated to arterial health may not benefit from this research.
What this research studies
This research investigates how targeting a specific protein, ALDH1A3, can help improve the healing of blood vessels after procedures like angioplasty. By using advanced techniques to reduce the levels of ALDH1A3, the study aims to enhance the recovery of endothelial cells, which line the blood vessels, and prevent complications such as inflammation and re-narrowing of the arteries. The approach includes both laboratory experiments and animal models to test the effectiveness of this targeted therapy. Patients may benefit from improved outcomes following vascular surgeries if the findings are successful.
Why it matters
Potential benefit: If successful, this research could lead to better healing and reduced complications for patients undergoing vascular surgeries.
How similar studies have gone: Previous research has shown promising results in targeting ALDH1A3 for vascular health, indicating potential for success in this approach.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Kent, K Craig — University of Virginia
- Study coordinator: Kent, K Craig
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.