Reducing alcohol-related brain and thinking problems in people with HIV
Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection
This project tries to lower the harm alcohol causes to the gut and brain in people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11163365 on NIH RePORTER |
What this research studies
Researchers will study how drinking affects the gut microbiome, gut leakiness, inflammation, and brain health in people with HIV. They will collect clinical samples, do cognitive and brain testing, and follow links between gut changes and thinking problems. The team will try interventions to help people drink less or protect the brain, including approaches that target the gut or inflammation. Work is carried out through the Southern HIV & Alcohol Research Consortium and is connected to community and training programs.
Who could benefit from this research
Good fit: Adults living with HIV who drink alcohol and are concerned about memory, thinking, or brain health would be the most likely candidates.
Not a fit: People without HIV, those who do not drink alcohol, or those whose cognitive problems come from unrelated causes are unlikely to benefit from these specific interventions.
Why it matters
Potential benefit: If successful, this work could reduce cognitive problems and protect brain health for people with HIV who drink alcohol.
How similar studies have performed: Prior research has linked alcohol, the gut microbiome, and inflammation to brain problems in HIV, but targeted gut–brain interventions in this group are still fairly new.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Cook, Robert L — University of Florida
- Study coordinator: Cook, Robert L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.