Reducing alcohol intake by targeting the brain's reward circuit
Mechanisms underlying the reduction in alcohol intake in response to low intensity targeting of the reward circuit
This research explores a new way to help people with alcohol use disorder by using gentle ultrasound to change how the brain's reward system works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11088145 on NIH RePORTER |
What this research studies
We are looking into a new method that uses low-intensity focused ultrasound (LIFU) combined with a special imaging technique to precisely target areas in the brain linked to addiction. Our goal is to understand how this non-invasive approach can reduce the desire for alcohol. We want to learn how long these effects might last and if there are any side effects on the brain. This work could lead to new ways to help individuals struggling with alcohol use disorder.
Who could benefit from this research
Good fit: This foundational research is currently conducted in animal models, but future human studies would likely seek individuals diagnosed with alcohol use disorder.
Not a fit: Patients not struggling with alcohol use disorder would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this approach could offer a new, non-invasive treatment option for individuals with alcohol use disorder, potentially reducing alcohol consumption and improving recovery rates.
How similar studies have performed: Preliminary work has shown that this ultrasound approach can reduce alcohol intake and preference in animal models, suggesting a promising direction.
Where this research is happening
Tampa, United States
- University of South Florida — Tampa, United States (Active)
Researchers
- Principal investigator: Jiang, Huabei — University of South Florida
- Study coordinator: Jiang, Huabei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.