Redox switches in heart and blood vessel health
Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and Disease
Looking at whether enzymes that control cellular oxidation influence heart and blood vessel health for people with cardiovascular disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11237115 on NIH RePORTER |
What this research studies
This program focuses on a family of enzymes called CYB5R that help control oxidation chemistry in heart and blood vessel cells. Researchers will use cell-type specific knockouts in lab models to see how these enzymes work in endothelial cells, smooth muscle, and heart muscle cells. They will use a lab 'biopanning' method to find the proteins that interact with these enzymes and study how those interactions change cell signaling. The team will also analyze large human genetic datasets (about 8,500 people) to see whether common gene variants relate to cardiovascular risk or biology.
Who could benefit from this research
Good fit: People with or at risk for cardiovascular disease, or those willing to share genetic and health data, would be most relevant to this research.
Not a fit: Patients seeking immediate new treatments are unlikely to benefit directly, since the work is primarily basic and translational rather than a clinical therapy trial.
Why it matters
Potential benefit: If successful, this work could reveal new biological targets or genetic markers that help guide future treatments for heart and vascular disease.
How similar studies have performed: Previous work has linked CYB5R3 to redox control in the cardiovascular system, but studying the other CYB5R family members and their binding partners is largely novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Straub, Adam Carl — University of Pittsburgh at Pittsburgh
- Study coordinator: Straub, Adam Carl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.