Redox control of protein kinase function in cancer and heart disease
Official title: Redox regulation of protein kinase function: biochemical mechanisms and cellular consequences
Funded at North Carolina Agri & Tech St Univ · NIH-11370258 · Data updated 2026-11-12
A grant exploring how oxidative changes affect protein kinases could reveal new ways to treat cancer and cardiovascular diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Agri & Tech St Univ NIH-funded |
| Lab location | 1 site (Greensboro, United States) |
| Project start | August 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $362,500 |
| NIH project number | 5R35GM153737-03 |
| Project ID | NIH-11370258 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with cancers or cardiovascular conditions where redox-regulated signaling is implicated and who may benefit from future targeted therapies.
✕Less likely to help
People without diseases linked to redox-regulated kinase signaling may not benefit directly.
What this research studies
This project looks at how reactive oxygen species change kinase signaling inside cells and how those changes influence disease-related pathways. By studying how reversible oxidation of cysteine residues alters kinase activity and interactions, researchers aim to map how signaling networks reconfigure under stress. The work combines biochemistry and cell biology to understand how redox modifications affect MAP kinase pathways and substrate choices. Findings could identify new targets for therapies that modulate redox regulation in disease.
Why it matters
Potential benefit: If successful, the research could lead to novel strategies to correct kinase signaling in cancer and cardiovascular diseases.
How similar studies have gone: Previous work shows redox regulation of kinases can alter activity, localization, and interactions, supporting potential for translational impact.
Where this research is happening
-
North Carolina Agri & Tech St Univ
Greensboro, United States Active
Researchers
- Principal investigator: Newman, Robert Howard — North Carolina Agri & Tech St Univ
- Study coordinator: Newman, Robert Howard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.