Red blood cells transport a protein linked to Alzheimer's disease and heart issues.
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
This study is looking at how red blood cells might help move a protein linked to Alzheimer's disease between the brain and heart, and it aims to find out how our genes affect this process, which could give us new ideas about how Alzheimer's progresses and its effects on heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10768646 on NIH RePORTER |
What this research studies
This research investigates how red blood cells (RBCs) may play a role in transporting beta-amyloid, a protein associated with Alzheimer's disease, between the brain and the heart. The study aims to understand the genetic factors that influence the levels of complement receptor 1 (CR1) on RBCs and how these levels affect the clearance of beta-amyloid from the bloodstream. By examining the relationship between RBCs, beta-amyloid, and the complement system, the research seeks to uncover new insights into the progression of Alzheimer's disease and its potential impact on heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, particularly those with varying genetic expressions of CR1 on their red blood cells.
Not a fit: Patients without Alzheimer's disease or significant cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease and related cardiovascular issues.
How similar studies have performed: Previous research has indicated a connection between beta-amyloid and Alzheimer's disease, but this specific approach examining RBCs and CR1 levels is relatively novel.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Del Monte, Federica — Medical University of South Carolina
- Study coordinator: Del Monte, Federica
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.