Recruiting and keeping older adults in a statin program to help prevent dementia
PREVENTABLE Recruitment and Retention
This project is testing whether a moderate-dose statin can help people aged 75 and older stay free of dementia and live longer without disability.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11179157 on NIH RePORTER |
What this research studies
You would be invited to join a large national effort that randomizes 20,000 people aged 75 and up to receive a moderate-intensity statin or usual care. The team is focused on making it easier for older adults—including very old people, those with frailty, limited mobility, mild cognitive problems, and multiple health conditions—to join and stay in the effort. They will use tailored recruitment and retention strategies to reach women, racial and ethnic minorities, and people across most U.S. regions. The core work includes simplifying consent, reducing visit burdens, addressing transportation and caregiver concerns, and engaging clinicians to support referrals.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 75 or older without known coronary heart disease who can attend local study visits and are willing to try a moderate-intensity statin or usual care.
Not a fit: People younger than 75, those with existing clinically evident coronary heart disease, or those unable to participate in follow-up visits are unlikely to be eligible or benefit from this trial.
Why it matters
Potential benefit: If successful, this could show a widely available medicine helps prevent dementia and prolongs disability-free life in people over 75.
How similar studies have performed: Observational studies and smaller trials have produced mixed results about statins and cognition, so this very large randomized effort addresses an important unanswered question.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Jones, William S — Duke University
- Study coordinator: Jones, William S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.