Recording brain activity in freely-moving animals to understand neural circuits
Official title: Untethered high channel count electrophysiology for freely-moving animals
Funded at Leaflabs, LLC · NIH-10896315 · Data updated 2026-11-12
This study is looking at how groups of brain cells work together in animals as they move around, which could help us understand conditions like Alzheimer's and Parkinson's better and lead to new ways to treat them.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leaflabs, LLC NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $547,747 |
| NIH project number | 5R43MH134730-02 |
| Project ID | NIH-10896315 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals affected by neurological conditions, particularly those with Alzheimer's disease or related disorders.
✕Less likely to help
Patients without neurological conditions or those who are not affected by cognitive impairments may not receive direct benefits from this research.
What this research studies
This research focuses on recording the activity of large populations of neurons in the brains of freely-moving animals with high precision. By using advanced technology that allows for simultaneous recording from thousands of neurons, the project aims to explore how these neurons interact and how their activity relates to behavior. The findings could provide insights into neurological conditions like Alzheimer's and Parkinson's disease, potentially leading to new treatment strategies. The research employs innovative electrophysiology techniques to gather data that could enhance our understanding of brain function.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating neurological disorders such as Alzheimer's disease.
How similar studies have gone: Other research has shown success with similar high-channel electrophysiology approaches, indicating potential for significant advancements in understanding brain function.
Where this research is happening
-
Leaflabs, LLC
Cambridge, United States Active
Researchers
- Principal investigator: Sherwood, John L — Leaflabs, LLC
- Study coordinator: Sherwood, John L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.