Recording brain activity at the single-cell level over long periods.
Official title: Temporally scalable recording of brain-wide single-cell physiology
Funded at University of Michigan at Ann Arbor · NIH-10907260 · Data updated 2026-11-12
This study is exploring a new way to track brain activity and gene changes in individual brain cells for a long time, which could help us learn more about brain health and conditions like Alzheimer's or Parkinson's, all without using any devices that might disrupt the cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 10, 2024 |
| Project end | September 9, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,345,424 |
| NIH project number | 1DP2MH140133-01 |
| Project ID | NIH-10907260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals experiencing neurological disorders or age-related cognitive decline.
✕Less likely to help
Patients with acute neurological injuries or conditions that do not involve long-term brain function changes may not benefit from this research.
What this research studies
This research focuses on developing a new technology that allows for the long-term recording of brain activity and gene expression at the single-cell level. By creating a genetically encoded system, researchers aim to monitor cellular signaling and physiological changes in the brain without the need for external devices that can interfere with the cells. This innovative approach could provide insights into various neurological disorders and the effects of aging, potentially leading to a better understanding of brain function over time.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating neurological disorders related to aging, memory, and learning.
How similar studies have gone: While there have been advancements in single-cell recording technologies, this approach is novel and aims to overcome significant limitations of existing methods.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Linghu, Changyang — University of Michigan at Ann Arbor
- Study coordinator: Linghu, Changyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.