Rebuilding Chromosomes to Address Infertility
Reconstructing Somatic Chromosomes
This project explores how chromosomes can be rearranged in eggs using a special cell transfer method, hoping to find new solutions for infertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11121042 on NIH RePORTER |
What this research studies
This project looks at a process called somatic cell nuclear transfer (SCNT), which involves replacing the genetic material in an egg with genetic material from a regular body cell. Normally, eggs created this way are not suitable for pregnancy because they have too many chromosomes, a condition known as triploidy. However, early findings suggest these modified eggs might be able to properly sort their chromosomes. Researchers are working to understand how to encourage these chromosomes to pair up correctly in mouse eggs. The ultimate goal is to create new treatment options for people who struggle with infertility due to chromosome issues.
Who could benefit from this research
Good fit: Future applications of this basic research may benefit individuals experiencing infertility, particularly those with chromosomal abnormalities like triploidy.
Not a fit: Patients whose infertility is not related to chromosomal abnormalities or triploidy are unlikely to directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could lead to new fertility treatments for individuals facing specific chromosome-related infertility challenges, such as triploidy.
How similar studies have performed: This project builds on preliminary studies showing promising initial results with SCNT oocytes, suggesting a novel approach to addressing chromosome segregation.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Mitalipov, Shoukhrat — Oregon Health & Science University
- Study coordinator: Mitalipov, Shoukhrat
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.