Real-world diabetes prevention programs across university and regional health systems

DP22-001 Evaluating Real-world Diabetes Prevention Programs in a Multi-campus University System and a Three-state Regional Health Network

NIH-funded research University of California Los Angeles · NIH-11112282

This project compares long-term weight and health outcomes for adults at risk for type 2 diabetes who complete, start-but-don't-complete, or don't join Diabetes Prevention Programs in two large health systems.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionUniversity of California Los Angeles NIH-funded
Lab location1 site (Los Angeles, United States)
Project IDNIH-11112282 on NIH RePORTER

What this research studies

You would be part of a large merged group made from electronic health records, insurance claims, and Diabetes Prevention Program (DPP) cohort data from the University of California system and Intermountain Healthcare. Researchers will match people who did not enroll with those who enrolled to fairly compare outcomes, and they will include all DPP delivery models used over nearly a decade. The main measure is percent weight change over five years, and they will also look at blood pressure, tobacco use, other cardiovascular risk factors, and cost-effectiveness. The team will study barriers and facilitators to joining and completing DPP to learn what helps people stick with programs.

Who could benefit from this research

Good fit: Adults at elevated risk for type 2 diabetes (for example, people with prediabetes or other risk factors) who receive care or have records within the participating UC or Intermountain systems would be the ideal group.

Not a fit: People without prediabetes or established type 2 diabetes, or those who do not receive care within the participating health systems, are unlikely to be included or directly benefit from this project.

Why it matters

Potential benefit: If successful, the findings could show which DPP delivery methods produce lasting weight loss and better heart-health metrics and help more at-risk people access effective prevention.

How similar studies have performed: Randomized DPP trials have proven diabetes prevention and weight loss, but real-world implementations have produced mixed results, so this large multi-system analysis builds on known successes but addresses real-world variability.

Where this research is happening

Los Angeles, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.