Real-time heart electrical monitoring with nerve-guided therapy
Bioelectric monitoring and neuromodulation of the heart
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11336907
This project is creating tiny heart sensors and nerve-control technology to spot and stop dangerous heart rhythms for people with arrhythmias or structural heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11336907 on ClinicalTrials.gov |
What this research studies
Researchers will develop thin, flexible electrode arrays that can record electrical signals from the heart and nearby nerves in real time. They will apply advanced data analysis to detect patterns that often precede serious arrhythmias. When a risky pattern is found, the system will deliver targeted nerve stimulation to try to prevent the arrhythmia from progressing. Initial work will be done in the lab and models with the goal of moving toward use in patients who need close monitoring or surgery.
Who could benefit from this research
Good fit: People with significant heart rhythm disorders (for example atrial or other recurrent arrhythmias) or patients undergoing cardiac surgery would be the most likely candidates.
Not a fit: People without arrhythmia risk, with only mild well-controlled palpitations, or with incompatible implanted devices may not benefit from this technology.
Why it matters
Potential benefit: If successful, this approach could detect and stop life-threatening arrhythmias earlier, lowering the risk of cardiac arrest and complications from heart procedures.
How similar studies have performed: Implantable pacemakers and defibrillators already control dangerous rhythms and some experimental neuromodulation approaches have shown promise, but this high-resolution closed-loop system is a newer, more experimental advance.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHIVKUMAR, KALYANAM — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: SHIVKUMAR, KALYANAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.