Real-time health risk warnings using wearables and medical records
Real time risk prognostication via scalable hazard trees and forests
This project builds tools that use wearables and electronic health records to give real-time risk warnings for people with heart failure on transplant waiting lists.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11333789 on NIH RePORTER |
What this research studies
The team will combine data from wearable sensors and your electronic health records to track how your risk changes over time. They will use machine-learning methods called hazard trees and forests to model time-dependent risks and handle many complex variables and interactions. Open-source software implementing these methods will be developed so hospitals and clinicians can run the models. The tools will be trained and tested on data from heart failure patients listed for heart transplantation across multiple centers to produce a 'state of heart' risk model that updates as your data change.
Who could benefit from this research
Good fit: Adults with advanced heart failure who are listed for heart transplantation and who have wearable sensor data and linked electronic health records are the ideal candidates.
Not a fit: People without wearable monitoring or linked medical records, those not represented in the transplant datasets, or patients with conditions not covered by the model may not see benefits.
Why it matters
Potential benefit: If successful, this could provide earlier, personalized warnings of worsening heart status for transplant-listed patients so clinicians can act sooner.
How similar studies have performed: Related time-varying survival and machine-learning approaches have shown promise in predicting clinical risk, but applying scalable hazard trees and forests to transplant-listed heart failure patients is relatively new.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Ishwaran, Hemant — University of Miami School of Medicine
- Study coordinator: Ishwaran, Hemant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.