Rare and Atypical Diabetes Network (RADIANT)
RADIANT
This project looks for the causes and different types of uncommon diabetes by collecting medical data, genetic and blood tests, and patient-derived cells from people with atypical forms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11076265 on NIH RePORTER |
What this research studies
If you join, the network will collect your medical history and detailed physical and lab measurements, and may ask for blood samples and family member information. They perform whole genome sequencing, RNA sequencing, and detailed blood metabolite testing to search for genetic and molecular signatures. Researchers also make patient-derived stem cells to study how a person’s own cells behave in the lab. The team uses a coordinated pipeline across centers to harmonize screening, deep phenotyping, and data analysis.
Who could benefit from this research
Good fit: Ideal candidates are people whose diabetes does not fit classic type 1 or type 2 categories—including suspected monogenic diabetes, ketosis-prone, brittle, or other atypical presentations—and sometimes informative family members.
Not a fit: People with typical, well-characterized type 1 or type 2 diabetes with no unusual features are less likely to benefit directly from this network.
Why it matters
Potential benefit: This could help people with unusual diabetes get a clearer diagnosis, identify underlying causes, and open the door to more personalized treatments.
How similar studies have performed: Previous genetic and precision-medicine efforts have identified new monogenic causes and subtypes of diabetes, but this integrated network approach combining genomics, metabolomics, and patient-derived cells is relatively novel at scale.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Balasubramanyam, Ashok — Baylor College of Medicine
- Study coordinator: Balasubramanyam, Ashok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.