Rapid, Sensitive Oral Fluid Fentanyl Test that’s Easy to Use
Official title: A Rapid, Sensitive and Instrument-free Oral Fluid Fentanyl Test
Funded at Instanosis, INC. · NIH-11348190 · Data updated 2026-11-12
A fast, easy-to-use test will help people in emergencies or at home know if fentanyl is present in their saliva so they can get the right care quickly.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Instanosis, INC. NIH-funded |
| Lab location | 1 site (Milford, United States) |
| Project start | June 15, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,414,924 |
| NIH project number | 5R44DA061963-02 |
| Project ID | NIH-11348190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals at risk of fentanyl exposure or overdose, emergency responders, and facilities seeking rapid fentanyl screening.
✕Less likely to help
People without fentanyl exposure or those needing more comprehensive testing may not directly benefit.
What this research studies
This project aims to finalize a saliva-based fentanyl test that is highly sensitive and usable without special equipment. Building on a successful urine test and FDA Breakthrough Device recognition, the team will integrate prototype parts into a final design suitable for OTC use. It focuses on detecting fentanyl in oral fluid to enable timely naloxone administration and appropriate clinical decisions in emergency settings. The work is centered on making a usable, rapid test that can be performed outside traditional laboratory environments.
Why it matters
Potential benefit: If successful, the test could enable rapid, at-home or on-scene fentanyl detection to improve emergency response and patient outcomes.
How similar studies have gone: A rapid urine fentanyl test exists and has FDA Breakthrough Device status, supporting potential success for the oral fluid version.
Where this research is happening
-
Instanosis, INC.
Milford, United States Active
Researchers
- Principal investigator: Xia, Xiaofeng — Instanosis, INC.
- Study coordinator: Xia, Xiaofeng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.