Rapid identification of congenital CMV and neonatal HSV infections using a small blood sample
NeoChip for specific and rapid identification of congenital CMV and neonatal HSV infections on minimal sample volume
['FUNDING_R01'] · UNIVERSITY OF UTAH · NIH-10874546
This study is testing a new, faster way to identify infections like congenital cytomegalovirus and neonatal herpes in newborns using a small blood sample, so that babies can get the right treatment sooner and have better health outcomes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10874546 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method to quickly and accurately identify congenital cytomegalovirus (cCMV) and neonatal herpes simplex virus (nHSV) infections in newborns. The approach utilizes a technique called Universal High Resolution Melt (U-HRM) that analyzes pathogen DNA from minimal blood samples, allowing for faster diagnosis compared to traditional methods like viral culture and PCR. By employing machine learning technology, the study aims to generate unique genetic 'fingerprints' of the viruses, which can lead to timely treatment and better outcomes for affected infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns, particularly those under 4 weeks old, who may be at risk for cCMV or nHSV infections.
Not a fit: Patients who are older than 11 years or those without any symptoms or risk factors for cCMV or nHSV infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the time to diagnose serious viral infections in newborns, leading to earlier interventions and improved health outcomes.
How similar studies have performed: Previous research has shown promising results with similar rapid diagnostic techniques, indicating potential for success in this novel approach.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAWRENCE, SHELLEY M — UNIVERSITY OF UTAH
- Study coordinator: LAWRENCE, SHELLEY M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.