Rapid hip fracture surgery for patients with recent heart injury
HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial
['FUNDING_U01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10897209
This project compares having hip fracture surgery within six hours versus usual timing for people whose blood tests show an acute heart injury.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10897209 on ClinicalTrials.gov |
What this research studies
If you arrive at the hospital with a broken hip and a blood test (troponin) shows acute heart injury, doctors would randomly assign you to have surgery within six hours or to receive the hospital's usual timing. The trial runs at multiple hospitals and follows patients for 90 days after surgery. Researchers will measure death rates, whether patients can walk 10 feet independently at 90 days, patient-reported quality of life, and medical or surgical complications. The goal is to confirm earlier findings that suggested people with heart injury fare better with earlier operations.
Who could benefit from this research
Good fit: Ideal candidates are adults hospitalized with a hip fracture whose blood troponin is elevated, indicating a recent heart injury, and who can be randomized to different surgery timing.
Not a fit: Patients without an elevated troponin, those who are too unstable for early surgery, or those who decline randomization are unlikely to receive benefit from this study's intervention.
Why it matters
Potential benefit: If successful, faster surgery could lower the risk of death and improve recovery and quality of life after hip fracture for people with acute heart injury.
How similar studies have performed: Prior subgroup analyses suggested benefit from accelerated surgery in patients with elevated troponin, but this randomized trial is the first large, definitive test of that finding.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: O'TOOLE, ROBERT V. — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: O'TOOLE, ROBERT V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.