Rapid hip fracture surgery for patients with recent heart injury
Official title: HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial
Funded at University of Maryland Baltimore · NIH-10897209 · Data updated 2026-11-12
This project compares having hip fracture surgery within six hours versus usual timing for people whose blood tests show an acute heart injury.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $795,573 |
| NIH project number | 5U01AR080377-03 |
| Project ID | NIH-10897209 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults hospitalized with a hip fracture whose blood troponin is elevated, indicating a recent heart injury, and who can be randomized to different surgery timing.
✕Less likely to help
Patients without an elevated troponin, those who are too unstable for early surgery, or those who decline randomization are unlikely to receive benefit from this study's intervention.
What this research studies
If you arrive at the hospital with a broken hip and a blood test (troponin) shows acute heart injury, doctors would randomly assign you to have surgery within six hours or to receive the hospital's usual timing. The trial runs at multiple hospitals and follows patients for 90 days after surgery. Researchers will measure death rates, whether patients can walk 10 feet independently at 90 days, patient-reported quality of life, and medical or surgical complications. The goal is to confirm earlier findings that suggested people with heart injury fare better with earlier operations.
Why it matters
Potential benefit: If successful, faster surgery could lower the risk of death and improve recovery and quality of life after hip fracture for people with acute heart injury.
How similar studies have gone: Prior subgroup analyses suggested benefit from accelerated surgery in patients with elevated troponin, but this randomized trial is the first large, definitive test of that finding.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: O'toole, Robert V. — University of Maryland Baltimore
- Study coordinator: O'toole, Robert V.
Related research
Other NIH-funded projects on the same topics.
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MAC-STILA: Safer, gentler anesthesia for hip fracture in older adults
A multi-center trial tests a new anesthesia approach (MAC-STILA) to reduce delirium and other problems after hip-fracture surgery in older adults with dementia.
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HIP ATTACK-2: Faster surgery for hip fracture patients with heart injury
A multicenter trial tests whether operating within 6 hours after hip fracture improves survival and recovery for patients who also have acute heart injury.
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Hip fracture risk in people with chronic kidney disease
A study focused on why hip fractures happen and how to prevent them in people with chronic kidney disease.
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How bones weaken in different ways that lead to hip fractures
This project looks at how differences in bone size, mineral content, and bone area relate to hip fracture risk in older men and women.
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Monitored sedation with local anesthetic injections for older adults with hip fracture
This project compares monitored sedation plus local anesthesia injections to standard general anesthesia for older adults having hip fracture surgery to reduce postoperative delirium.
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Developing a new treatment to improve muscle recovery after hip fractures in older adults
This study is testing a new pill called RT-002 to see if it can help older adults heal better and regain strength after a hip fracture, with the hope of making their recovery easier and improving their overall quality of life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.