Rapid bedside test for talaromycosis in people with advanced HIV
Development, Clinical Validation, and Readiness for Implementation of a Novel Mp1p D4 Poin Diagnosis of Talaromycosist of Care Test for Rapid
A quick bedside test to find talaromycosis early in people with advanced HIV so treatment can start sooner.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11522901 on NIH RePORTER |
What this research studies
You would get a quick bedside test that looks for a protein from the talaromycosis fungus to detect infection much earlier than slow culture tests. Researchers will refine the test in the lab, then check how it performs using blood samples and medical records from people in high-risk areas. They will compare the test to standard culture diagnosis, test its ability to pick up infection weeks earlier, and gather feedback from patients and clinicians about using it in clinics. The team will also work on steps to bring the test into routine care in places like Vietnam, Thailand, and China.
Who could benefit from this research
Good fit: Ideal candidates are people with advanced HIV (low CD4 counts) in areas where Talaromyces marneffei is common, especially in Southeast Asia.
Not a fit: People without HIV or those living in non-endemic regions are unlikely to benefit directly from this test.
Why it matters
Potential benefit: If successful, the test could allow earlier treatment and reduce deaths from talaromycosis among people with advanced HIV.
How similar studies have performed: This point-of-care approach is novel for talaromycosis—current diagnostics rely on slow culture, though lab-based antigen tests have suggested earlier detection is possible.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Le, Thuy — Duke University
- Study coordinator: Le, Thuy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.