Raising NAD levels to reduce inflammation in heart failure
Official title: Boosting NAD to Combat Heart Failure Sterile Inflammation
Funded at VA Puget Sound Healthcare System · NIH-11213916 · Data updated 2026-11-12
This project will try boosting the body's NAD levels to calm harmful inflammation in people with heart failure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Puget Sound Healthcare System NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2028 |
| Funding year | 2026 |
| NIH project number | 5IK2BX006111-03 |
| Project ID | NIH-11213916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic heart failure, particularly those showing persistent low-level inflammation, are the most likely candidates for this work.
✕Less likely to help
People without heart failure or whose condition is not driven by inflammatory processes are unlikely to gain benefit from this approach.
What this research studies
I have heart failure and this research is exploring how tiny particles in the blood called extracellular vesicles may carry damaged mitochondrial pieces that trigger ongoing inflammation and worsen heart function. The team will study how my immune cells respond to those mitochondrial signals and whether increasing NAD+ can block that harmful immune activation. They will combine lab experiments with analysis of patient samples and small clinical data to trace these signals and test NAD-boosting approaches. The goal is to turn those findings into ways to lower inflammation in people living with heart failure.
Why it matters
Potential benefit: If successful, this could lead to treatments that reduce inflammation, slow heart failure progression, and improve symptoms and outcomes.
How similar studies have gone: Early animal studies and small human trials of NAD boosters show anti-inflammatory effects, but there are no large definitive trials in heart failure yet.
Where this research is happening
-
VA Puget Sound Healthcare System
Seattle, United States Active
Researchers
- Principal investigator: Wang, Dennis Ding Hwa — VA Puget Sound Healthcare System
- Study coordinator: Wang, Dennis Ding Hwa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.