Raising NAD levels to reduce inflammation in heart failure
Boosting NAD to Combat Heart Failure Sterile Inflammation
['FUNDING_OTHER'] · VA PUGET SOUND HEALTHCARE SYSTEM · NIH-11213916
This project will try boosting the body's NAD levels to calm harmful inflammation in people with heart failure.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA PUGET SOUND HEALTHCARE SYSTEM (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11213916 on ClinicalTrials.gov |
What this research studies
I have heart failure and this research is exploring how tiny particles in the blood called extracellular vesicles may carry damaged mitochondrial pieces that trigger ongoing inflammation and worsen heart function. The team will study how my immune cells respond to those mitochondrial signals and whether increasing NAD+ can block that harmful immune activation. They will combine lab experiments with analysis of patient samples and small clinical data to trace these signals and test NAD-boosting approaches. The goal is to turn those findings into ways to lower inflammation in people living with heart failure.
Who could benefit from this research
Good fit: Adults with chronic heart failure, particularly those showing persistent low-level inflammation, are the most likely candidates for this work.
Not a fit: People without heart failure or whose condition is not driven by inflammatory processes are unlikely to gain benefit from this approach.
Why it matters
Potential benefit: If successful, this could lead to treatments that reduce inflammation, slow heart failure progression, and improve symptoms and outcomes.
How similar studies have performed: Early animal studies and small human trials of NAD boosters show anti-inflammatory effects, but there are no large definitive trials in heart failure yet.
Where this research is happening
SEATTLE, UNITED STATES
- VA PUGET SOUND HEALTHCARE SYSTEM — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, DENNIS DING HWA — VA PUGET SOUND HEALTHCARE SYSTEM
- Study coordinator: WANG, DENNIS DING HWA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.