Radiogenomics to identify which pancreatic cysts (IPMNs) are likely to become cancer
Using Radiogenomics to Noninvasively Predict the Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Uncover Hidden Biology
This project combines CT scan features, AI, and blood markers to help people with pancreatic cysts (IPMNs) know which cysts are more likely to turn into cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-11176796 on NIH RePORTER |
What this research studies
If I have a pancreatic cyst called an IPMN, this work uses detailed features extracted from my CT scans together with a blood-based microRNA test and new AI methods to learn which cysts behave dangerously. The team links imaging patterns (radiomics) to underlying biology to find noninvasive signs of malignancy. Over the extension period they will add newer AI techniques and additional blood and behavioral markers to improve accuracy. The goal is to give clearer information to patients and doctors so they can choose surveillance versus surgery more safely.
Who could benefit from this research
Good fit: Ideal candidates are people with radiologically detected pancreatic cysts, especially those thought to be IPMNs who are facing decisions about surveillance versus surgery.
Not a fit: People without pancreatic cysts or with other unrelated pancreatic diseases or those whose cysts have already been removed are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this approach could reduce unnecessary surgery and help catch high-risk cysts earlier through more accurate noninvasive testing.
How similar studies have performed: Prior radiomics and blood-based microRNA studies have shown promise but have not yet replaced current clinical decision-making, so this work builds on encouraging but still-developing evidence.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Permuth, Jennifer B — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Permuth, Jennifer B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.