Quick automated MRI to measure the heart's energy use in heart failure
Push-Button Cardiac MRI for Non-Invasive Quantification of Myocardial Energy Consumption in Heart Failure
A fast, push-button MRI method to measure how much energy the heart uses in people with heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11162464 on NIH RePORTER |
What this research studies
This project is creating an automated ‘push-button’ cardiac MRI that measures myocardial oxygen consumption (MVO2) without invasive catheters. The aim is a noninvasive, repeatable scan patients could get during clinic visits to track heart energy use over time. Researchers will adapt MRI techniques alongside new imaging software to produce reliable, quantitative results. If it works, the scan could help monitor disease progression and treatment response more easily.
Who could benefit from this research
Good fit: People with diagnosed or suspected heart failure who can safely undergo MRI (no incompatible implanted devices) are the ideal candidates.
Not a fit: People without heart disease or those who cannot have MRI (for example, certain pacemakers, other incompatible implants, or severe claustrophobia) may not be eligible or benefit.
Why it matters
Potential benefit: Could provide safe, repeatable measurements of heart energy that help detect worsening heart function earlier and track response to therapies.
How similar studies have performed: Techniques like PET and MR spectroscopy have measured cardiac energetics but are less practical for routine follow-up, and a fully automated MRI approach is relatively new.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Yang, Hsin-Jung — Cedars-Sinai Medical Center
- Study coordinator: Yang, Hsin-Jung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.