Proteostasis and Heart Health: How Cells Share Stress Signals
Official title: Metabolic Regulation of Protein Folding Homeostasis
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-11271304 · Data updated 2026-11-12
A scientist plans to study how cells communicate stress signals that affect protein folding, with a focus on heart and brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | August 11, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $410,169 |
| NIH project number | 1R35GM162857-01 |
| Project ID | NIH-11271304 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants would be individuals with cardiovascular or neurodegenerative conditions where proteostasis may be disrupted, or those at risk due to family history.
✕Less likely to help
Healthy individuals without proteostasis-related risk factors may not directly benefit.
What this research studies
This project looks at how cells maintain protein balance and how disruptions can contribute to heart, metabolic, and brain diseases. Researchers will explore how protective stress responses in one tissue might influence others, using mammalian systems. The goal is to uncover how inter-tissue signaling modulates protein folding and identify potential targets for therapies that help the whole body stay healthy.
Why it matters
Potential benefit: If successful, findings could lead to new treatments that improve protein homeostasis across heart and brain tissues.
How similar studies have gone: Previous work has shown tissue communication affects stress responses, but mechanistic links in mammals remain to be clarified.
Where this research is happening
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Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Rosarda, Jessica Danielle — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Rosarda, Jessica Danielle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.