Proteins that control how cells release substances
Discovering protein networks underlying regulated exocytosis
This project maps the proteins that help cells release cargo like insulin-responsive glucose transporters, which is important for people with metabolic conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11289457 on NIH RePORTER |
What this research studies
This research focuses on regulated exocytosis, the signal-driven process cells use to deliver key molecules to the cell surface. Researchers use CRISPR-based genetic screens to find proteins that affect insulin-stimulated GLUT4 exocytosis and then perform biochemical and genetic follow-ups to determine how those proteins work. The team also studies how vesicle fusion is linked to clathrin-mediated endocytosis by examining assembly of the AP2 adaptor. Work is done in lab models at the University of Colorado to build a detailed map of the protein networks involved.
Who could benefit from this research
Good fit: People with diabetes, insulin resistance, or other disorders of insulin signaling would be most directly relevant to this research.
Not a fit: Those seeking immediate clinical treatment or people with conditions unrelated to cellular exocytosis are unlikely to receive direct benefit from this lab-based work.
Why it matters
Potential benefit: If successful, the findings could reveal new targets for drugs or therapies to improve insulin signaling and related metabolic diseases.
How similar studies have performed: Previous CRISPR screens have identified many candidate regulators, but the precise biochemical roles of many of these proteins remain novel and under characterization.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Shen, Jingshi — University of Colorado
- Study coordinator: Shen, Jingshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.