Proteins and lab tests for studying cancer-linked mutation enzymes
CORE B – PROTEINS & ASSAYS
This project makes proteins, antibodies, and lab tests to help scientists study enzymes that cause mutations in many cancers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11198651 on NIH RePORTER |
What this research studies
The team produces APOBEC3 proteins and special antibodies and builds lab tests that measure how these enzymes bind and act on DNA. They create standard procedures so results are reliable and can be shared across research groups. The core supplies these reagents and assays to researchers working on tumors with APOBEC-related mutation patterns. The group will also develop new tests and improve existing ones for broader use within the program and collaborators.
Who could benefit from this research
Good fit: Patients whose tumors show APOBEC-related mutation patterns or who are treated at the program's participating cancer centers would be most likely to benefit or be invited into related studies.
Not a fit: People without cancer or whose tumors do not show APOBEC-related mutations are unlikely to receive direct benefit from this work.
Why it matters
Potential benefit: If successful, these tools could speed up research that leads to treatments that slow or prevent mutation-driven cancer progression.
How similar studies have performed: Other labs and this core have previously produced APOBEC proteins and specific antibodies, so this builds on proven methods while expanding standardized assays.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Carpenter, Michael Allen — University of Texas Hlth Science Center
- Study coordinator: Carpenter, Michael Allen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.