Protein map of HIV and hepatitis B to help cure hepatitis B
A proteomics atlas of HIV/HBV infections for curing HBV
This project creates a detailed map of the proteins involved in HIV and hepatitis B infections to help develop cures for people living with chronic hepatitis B, including those co-infected with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11145950 on NIH RePORTER |
What this research studies
If you have chronic hepatitis B or HIV/HBV co-infection, researchers will map the proteins and molecular interactions that help the viruses persist. They will use advanced proteomics, CRISPR genetic screens, and lab models to find host proteins that either help or block HBV and HIV. The team will study how treatments like interferon-alpha affect the viral cccDNA that keeps HBV chronic. Findings may come from patient samples as well as cell-based experiments performed at the research site.
Who could benefit from this research
Good fit: Ideal candidates would be people with chronic hepatitis B, particularly those also living with HIV, who may be willing to provide clinical samples or participate in related observational studies.
Not a fit: People without chronic HBV (or those looking for immediate treatment effects) are unlikely to receive direct clinical benefit from this laboratory-focused research in the short term.
Why it matters
Potential benefit: Could identify new targets or mechanisms to eliminate or silence HBV cccDNA and move therapies closer to a cure, especially for people with HIV/HBV co-infection.
How similar studies have performed: Proteomics and CRISPR screening have successfully identified host factors for other viruses, but applying these tools specifically to HBV cccDNA and HIV/HBV co-infection is relatively new.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Michailidis, Eleftherios — Emory University
- Study coordinator: Michailidis, Eleftherios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.