Protein analysis to learn about aging and Alzheimer's disease
Official title: Processing and Analyzing Mass Spectrometry Proteomics Data for the Longevity Consortium
Funded at Translational Genomics Research Inst · NIH-11335153 · Data updated 2026-11-12
This project uses detailed protein measurements from people to find biological signs linked to aging, longevity, and Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Translational Genomics Research Inst NIH-funded |
| Lab location | 1 site (Phoenix, United States) |
| Project start | September 30, 2004 |
| Project end | August 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $50,000 |
| NIH project number | 3U19AG023122-17S1 |
| Project ID | NIH-11335153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants are older adults, including people with Alzheimer's or related dementias and very old individuals whose blood or tissue samples can be shared for analysis.
✕Less likely to help
People without available biological samples or those looking for immediate treatment options may not gain direct or immediate benefit from this project.
What this research studies
From your perspective, researchers are combining mass spectrometry protein data from many studies and populations to look for consistent protein signals tied to aging and Alzheimer's. They will integrate human data with cell and animal findings, run five focused projects, and build an Integrated Analysis Core to combine results. The team will re-analyze legacy samples and new datasets to find reliable biomarkers and possible targets for therapies. Results and data will be shared across the consortium to speed follow-up studies.
Why it matters
Potential benefit: If successful, this work could identify protein biomarkers that help detect Alzheimer's earlier or point to targets that slow aging-related decline.
How similar studies have gone: Previous proteomics studies have found promising protein biomarkers for aging and Alzheimer's, but this large-scale, multi-cohort integration is relatively new.
Where this research is happening
-
Translational Genomics Research Inst
Phoenix, United States Active
Researchers
- Principal investigator: Schork, Nicholas Joseph — Translational Genomics Research Inst
- Study coordinator: Schork, Nicholas Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.