Protecting the Heart from Damage During Heart Attacks
Acid, Succinate and Glyoxal Metabolism in Ischemia
This research explores new ways to protect the heart from damage that happens during heart attacks and cardiac surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11047684 on NIH RePORTER |
What this research studies
When someone has a heart attack or undergoes heart surgery, the heart muscle can be damaged when blood flow is interrupted and then restored. Our bodies have natural processes that might help protect the heart, like changes in acidity or certain natural chemicals. This project looks at how specific metabolic changes, including the roles of acid, succinate, and a molecule called methylglyoxal, affect heart cells during these stressful events. We are also exploring an enzyme called ALKBH7, which seems to play a role in heart cell death. Understanding these processes could lead to new ways to prevent or reduce heart damage.
Who could benefit from this research
Good fit: This fundamental research is relevant to adults experiencing acute myocardial infarction or undergoing cardiac surgery.
Not a fit: Patients not experiencing heart attacks or scheduled cardiac ischemia would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect the heart from injury during heart attacks or cardiac surgery, improving patient outcomes.
How similar studies have performed: This research builds on existing published and preliminary findings, exploring novel metabolic pathways for heart protection.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Brookes, Paul S — University of Rochester
- Study coordinator: Brookes, Paul S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.