Protecting the brain from injury after bleeding in the brain
Official title: Neurovascular protection by adropin in acute neural injury from subarachnoid hemorrhage
Funded at University of Florida · NIH-10884468 · Data updated 2026-11-12
This study is looking at how a hormone called adropin might help protect the brain after a type of bleeding called subarachnoid hemorrhage, with the goal of finding new ways to reduce brain damage and help patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $364,307 |
| NIH project number | 5R01NS124620-03 |
| Project ID | NIH-10884468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have survived a subarachnoid hemorrhage and are at risk for subsequent brain injury.
✕Less likely to help
Patients who have not experienced a subarachnoid hemorrhage or those with chronic brain injuries unrelated to this condition may not benefit from this research.
What this research studies
This research investigates how a hormone called adropin can help protect the brain from damage caused by subarachnoid hemorrhage, a type of bleeding in the brain. The study focuses on understanding the mechanisms behind brain injury following this event, particularly how adropin may improve blood flow and reduce oxidative stress. By examining the effects of adropin on brain cells and blood vessels, the researchers aim to find new therapeutic strategies to minimize brain damage and improve recovery outcomes for patients. The research involves both laboratory experiments and potential clinical applications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain injury and improve recovery for patients who experience subarachnoid hemorrhage.
How similar studies have gone: Previous research has shown promising results with similar approaches targeting neuroprotection in brain injuries, suggesting potential for success in this study.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Hoh, Brian Lim — University of Florida
- Study coordinator: Hoh, Brian Lim
Related research
Other NIH-funded projects on the same topics.
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Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
-
Blood test to predict delayed brain injury after an aneurysm bleed
This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
-
3D brain blood vessel model to study subarachnoid hemorrhage and test therapies
A researcher will develop a 3D printed, biomimetic brain model to study subarachnoid hemorrhage and screen potential nanoparticle-based treatments.
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Biomarkers to Fine-Tune Intrathecal Nicardipine for Brain Bleeding-Related Stroke
Researchers are testing biomarkers to personalize intrathecal nicardipine treatment for patients after subarachnoid hemorrhage to prevent brain damage.
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Adropin as a shield for the brain after a brain hemorrhage
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
-
Manganese-based compound as a potential therapy for subarachnoid hemorrhage
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.