Protecting the brain from damage caused by lack of oxygen before birth
Neuroprotection by nNOS inhibitors in perinatal hypoxia-ischemia
This study is looking at how certain medications might help protect newborns' brains from damage caused by a lack of oxygen, which can lead to cerebral palsy, and it's using rabbits to find out what could work best for future treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10794380 on NIH RePORTER |
What this research studies
This research investigates how specific inhibitors of neuronal nitric oxide synthase (nNOS) can protect the brain from damage caused by hypoxia-ischemia, a condition that can lead to cerebral palsy in newborns. Using a rabbit model that mimics human conditions of placental insufficiency, the study aims to identify effective neuroprotectants that could be translated into clinical therapies. Advanced MRI techniques will be employed to monitor brain responses and predict potential motor deficits in affected fetuses. The goal is to develop new treatments that could prevent the onset of cerebral palsy in infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals at risk of placental insufficiency or those who have experienced hypoxia-ischemia during pregnancy.
Not a fit: Patients who are not pregnant or those whose conditions do not involve hypoxia-ischemia will likely not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the incidence of cerebral palsy in newborns.
How similar studies have performed: Previous research has shown promise in using neuroprotectants for similar conditions, but this specific approach with nNOS inhibitors is relatively novel.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Tan, Sidhartha — Wayne State University
- Study coordinator: Tan, Sidhartha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.