Protecting the Brain After Aneurysmal Subarachnoid Hemorrhage
Roles of NAMPT and NAD+ in hypoxic conditioning-induced neurovascular protection in subarachnoid hemorrhage
This project explores how a special type of 'conditioning' can protect the brain from damage after a severe type of stroke called aneurysmal subarachnoid hemorrhage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11117006 on NIH RePORTER |
What this research studies
Aneurysmal subarachnoid hemorrhage (SAH) is a serious condition that can cause significant brain injury, both immediately after the event and several days later. This damage, known as Early Brain Injury (EBI) and Delayed Cerebral Ischemia (DCI), can lead to long-term problems. Our team is exploring a protective strategy called 'conditioning,' which helps the brain become more resistant to injury by exposing it to mild, non-harmful stress. We are specifically looking at how hypoxic conditioning, which involves brief periods of reduced oxygen, can protect brain cells and blood vessels after SAH. This work builds on earlier findings that showed this approach can reduce brain injury and improve outcomes in experimental models.
Who could benefit from this research
Good fit: This research is relevant for patients who have experienced or are at risk of aneurysmal subarachnoid hemorrhage and the resulting secondary brain injuries.
Not a fit: Patients without aneurysmal subarachnoid hemorrhage or those with other types of brain injury may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain damage and improve recovery for patients who experience aneurysmal subarachnoid hemorrhage.
How similar studies have performed: Previous work has shown that similar conditioning strategies can provide robust protection against brain injury in experimental models of subarachnoid hemorrhage.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Zipfel, Gregory J — Washington University
- Study coordinator: Zipfel, Gregory J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.