Protecting the Brain After Aneurysmal Subarachnoid Hemorrhage
Official title: Roles of NAMPT and NAD+ in hypoxic conditioning-induced neurovascular protection in subarachnoid hemorrhage
Funded at Washington University · NIH-11117006 · Data updated 2026-11-12
This project explores how a special type of 'conditioning' can protect the brain from damage after a severe type of stroke called aneurysmal subarachnoid hemorrhage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $527,494 |
| NIH project number | 5R01NS128082-03 |
| Project ID | NIH-11117006 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for patients who have experienced or are at risk of aneurysmal subarachnoid hemorrhage and the resulting secondary brain injuries.
✕Less likely to help
Patients without aneurysmal subarachnoid hemorrhage or those with other types of brain injury may not directly benefit from this specific research.
What this research studies
Aneurysmal subarachnoid hemorrhage (SAH) is a serious condition that can cause significant brain injury, both immediately after the event and several days later. This damage, known as Early Brain Injury (EBI) and Delayed Cerebral Ischemia (DCI), can lead to long-term problems. Our team is exploring a protective strategy called 'conditioning,' which helps the brain become more resistant to injury by exposing it to mild, non-harmful stress. We are specifically looking at how hypoxic conditioning, which involves brief periods of reduced oxygen, can protect brain cells and blood vessels after SAH. This work builds on earlier findings that showed this approach can reduce brain injury and improve outcomes in experimental models.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce brain damage and improve recovery for patients who experience aneurysmal subarachnoid hemorrhage.
How similar studies have gone: Previous work has shown that similar conditioning strategies can provide robust protection against brain injury in experimental models of subarachnoid hemorrhage.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Zipfel, Gregory J — Washington University
- Study coordinator: Zipfel, Gregory J
Related research
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Adropin as a shield for the brain after a brain hemorrhage
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
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Manganese-based compound as a potential therapy for subarachnoid hemorrhage
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.