Protecting the blood-brain barrier from damage caused by certain chemical exposures
Project 2: Protection of Blood-Brain Barrier Function
This study is looking at how certain chemicals can harm the protective barrier around the brain and cause serious health problems, and it aims to find new treatments that could help people recover better after such exposure, especially by reducing the chances of seizures and memory issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10911236 on NIH RePORTER |
What this research studies
This research investigates how exposure to specific chemical agents can disrupt the blood-brain barrier (BBB), leading to severe neurological issues. Using a rat model, the project aims to test therapies that could restore BBB function and prevent long-term neurological damage after acute exposure. The approach focuses on administering these therapies alongside standard care to see if they can reduce the risk of ongoing seizures and cognitive decline in survivors. By understanding and addressing BBB dysfunction, the research seeks to improve outcomes for individuals affected by these chemical exposures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been exposed to organophosphate chemicals and are at risk of neurological complications.
Not a fit: Patients who have not been exposed to organophosphate chemicals or who do not exhibit neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the brain from long-term damage after chemical exposure.
How similar studies have performed: While the specific approach of reversing BBB dysfunction in this context is novel, similar research has shown promise in understanding BBB integrity in other neurological conditions.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Gelli, Angie — University of California at Davis
- Study coordinator: Gelli, Angie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.