Protecting newborn brains from oxygen deprivation
Neonatal cerebral vascular injury by prolonged asphyxia
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-11123466
This project looks for new ways to protect the brain's blood vessels in newborns who experience a lack of oxygen at birth.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-11123466 on ClinicalTrials.gov |
What this research studies
When newborns don't get enough oxygen, it can harm their brain development, and current treatments don't fully prevent this damage. This work focuses on how oxygen deprivation affects the brain's blood vessels and the protective barrier between blood and brain. Researchers are exploring new ways to keep these vessels healthy by blocking harmful processes and boosting natural protective mechanisms. The goal is to find better treatments to prevent brain injury in these vulnerable infants.
Who could benefit from this research
Good fit: This foundational research focuses on understanding and treating brain injury in newborns who have experienced oxygen deprivation, particularly those 0-4 weeks old.
Not a fit: Patients outside the neonatal period or those with brain injuries not related to oxygen deprivation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that better protect the brains of newborns who experience oxygen deprivation at birth, potentially reducing long-term developmental problems.
How similar studies have performed: While hypothermia is a current treatment, this project explores novel mechanisms and combined therapies, representing a new approach to improving outcomes.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARFENOVA, HELENA — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: PARFENOVA, HELENA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.