Protecting Nerves in Familial Dysautonomia with Genipin
Genipin’s ECM Crosslinking Action as an Agent to Prevent Neurodegeneration in Familial Dysautonomia
This project explores how a natural compound called genipin might protect nerve cells and prevent nerve damage in children with Familial Dysautonomia, a serious genetic condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project ID | NIH-11224362 on NIH RePORTER |
What this research studies
Familial Dysautonomia (FD) is a serious genetic condition affecting children, leading to progressive nerve damage and a lack of effective treatments. This project investigates genipin, a natural compound found in Traditional Chinese Medicine, which has shown early promise in protecting nerve cells and preventing developmental issues in FD models. Researchers will explore how genipin works by focusing on its effects on the extracellular matrix, the support structure around cells, and other related molecules. Using advanced analysis of human and mouse models, the goal is to understand if genipin can prevent the nerve damage associated with FD.
Who could benefit from this research
Good fit: This research is focused on understanding Familial Dysautonomia, a genetic disorder primarily affecting children, and potential treatments for those with the condition.
Not a fit: Patients without Familial Dysautonomia would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to the first specific treatment to prevent nerve damage and improve the lives of children with Familial Dysautonomia.
How similar studies have performed: This project builds on previous successful work by the same team that identified genipin's potential, suggesting a promising, yet still early-stage, approach.
Where this research is happening
Athens, United States
- University of Georgia — Athens, United States (Active)
Researchers
- Principal investigator: Zeltner, Nadja — University of Georgia
- Study coordinator: Zeltner, Nadja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.