Protecting nerve fibers by improving their energy supply
Official title: Energizing and Protecting Axons Through Metabolic Coupling to Schwann Cells
Funded at Ohio State University · NIH-10869975 · Data updated 2026-11-12
This study is looking at ways to help protect nerve fibers from damage by boosting their energy supply with the help of special supporting cells, which could lead to better treatments for people with neurodegenerative diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 25, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $371,073 |
| NIH project number | 5R01NS123450-05 |
| Project ID | NIH-10869975 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from neurodegenerative diseases that involve axonal degeneration, such as multiple sclerosis or peripheral neuropathy.
✕Less likely to help
Patients with non-neurodegenerative conditions or those whose symptoms are not related to axonal health may not benefit from this research.
What this research studies
This research investigates how to protect nerve fibers, known as axons, by enhancing their energy supply through interactions with supporting cells called Schwann cells. The study focuses on understanding the molecular mechanisms that lead to axon degeneration, particularly in the context of neurodegenerative diseases. By exploring how energy depletion affects axon health, the research aims to develop new therapeutic strategies to prevent or slow down nerve damage. Patients may benefit from insights gained that could lead to improved treatments for conditions associated with axonal degeneration.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect nerve fibers and improve outcomes for patients with neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding axonal degeneration and bioenergetics, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Babetto, Elisabetta — Ohio State University
- Study coordinator: Babetto, Elisabetta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.