Protecting mothers' brains from injury and stroke after pregnancy complications
Official title: PROtecting Maternal brains from Injury and Stroke (PROMIS): a Single-center Phase 2 Clinical Trial
Funded at Columbia University Health Sciences · NIH-10799634 · Data updated 2026-11-12
This study is looking for ways to help new moms who have preeclampsia by finding better ways to spot those at risk for serious problems like strokes after giving birth, and it will explore personalized ways to manage their blood pressure to keep their brains healthy.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 2, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $205,625 |
| NIH project number | 5R21HD110992-02 |
| Project ID | NIH-10799634 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postpartum women who have experienced preeclampsia during their pregnancy.
✕Less likely to help
Patients who have not experienced preeclampsia or are not postpartum may not benefit from this research.
What this research studies
This research focuses on improving the health outcomes of mothers who experience preeclampsia, a condition that can lead to severe neurological issues after childbirth. It aims to develop better methods for identifying women at risk of complications like stroke and brain hemorrhage postpartum. The study will explore personalized blood pressure management strategies to optimize brain protection, taking into account individual variations in blood pressure response. By understanding how blood flow to the brain can be maintained, the research seeks to prevent serious health issues in new mothers.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of life-threatening neurological complications in postpartum women with a history of preeclampsia.
How similar studies have gone: While there has been some research on preeclampsia, this approach focusing on postpartum brain protection is relatively novel and has not been extensively tested.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Miller, Eliza C — Columbia University Health Sciences
- Study coordinator: Miller, Eliza C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.