Protecting Kidneys from Sepsis Damage
Endotoxin preconditioning as a model to uncover protective pathways in sepsis-induced renal injury
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11143855
This research explores how the body might naturally protect kidneys from damage caused by sepsis, a severe infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11143855 on ClinicalTrials.gov |
What this research studies
Sepsis, a severe infection, often leads to serious kidney damage, and current treatments haven't been very effective. Our team is looking into how cells in the kidney communicate and how this communication breaks down during sepsis, leading to injury. We've found that a specific part of the kidney, called the S1 tubule, takes in harmful substances from the infection, causing stress and damage to other kidney parts. We are also examining how certain enzymes and metabolic changes in these kidney cells contribute to this damage, hoping to find new ways to protect them.
Who could benefit from this research
Good fit: Patients who experience acute kidney injury due to sepsis could potentially benefit from future treatments developed from this fundamental understanding.
Not a fit: Patients whose kidney injury is not related to sepsis would likely not benefit directly from this specific line of research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or protective strategies for patients with sepsis-induced kidney injury.
How similar studies have performed: Previous attempts to find effective therapies for sepsis-induced kidney injury have not been successful, making this exploration of fundamental protective pathways a novel approach.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAGHER, PIERRE C — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: DAGHER, PIERRE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.