Protecting kidneys from damage during surgery
Novel mitochondrial protective properties of annexin A1
This study is looking at a new treatment that could help protect your kidneys during surgery from damage caused by acute kidney injury, using a special substance that may reduce kidney cell damage and improve their function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10868567 on NIH RePORTER |
What this research studies
This research focuses on developing new therapies to protect the kidneys from acute kidney injury (AKI) that can occur during surgeries. It investigates a novel peptide mimetic of annexin A1, which has shown promise in preliminary studies for reducing kidney cell death and improving mitochondrial function. By targeting the timing of kidney insults during surgeries, the research aims to create effective treatments that could be administered to patients at risk of AKI. The approach involves understanding how to limit metabolic stress on the kidneys, particularly during periods of reduced blood flow.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for vascular or transplant surgeries who are at risk of acute kidney injury.
Not a fit: Patients who are not undergoing surgery or those with pre-existing severe kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the risk of kidney damage in patients undergoing surgery.
How similar studies have performed: Other research has shown success with similar approaches in protecting organs from ischemic injury, indicating potential for this novel therapy.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Privratsky, Jamie R — Duke University
- Study coordinator: Privratsky, Jamie R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.