Protecting Kidneys from Cisplatin Chemotherapy
Kidney Injury by Cisplatin and Renoprotective Strategies
This project looks for ways to protect kidneys from damage caused by cisplatin, a common cancer medicine.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11164700 on NIH RePORTER |
What this research studies
Cisplatin is a powerful chemotherapy drug that can unfortunately harm the kidneys, sometimes leading to long-term kidney problems. This work aims to understand why this kidney damage happens and how it progresses, focusing on the role of ongoing inflammation. Researchers are exploring specific molecular pathways, like NF-kB and DNA methyltransferases, that seem to contribute to this inflammation. By understanding these pathways, we hope to find new ways to prevent or lessen kidney injury for cancer patients.
Who could benefit from this research
Good fit: Patients receiving cisplatin chemotherapy who are at risk of or experiencing kidney injury might eventually benefit from this research.
Not a fit: Patients not receiving cisplatin chemotherapy or those without kidney-related side effects from treatment would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect cancer patients' kidneys from the harmful side effects of cisplatin chemotherapy.
How similar studies have performed: Preliminary studies have shown promising results with inhibitors targeting the identified molecular pathways, suggesting these approaches could be effective.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Dong, Zheng — Augusta University
- Study coordinator: Dong, Zheng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.