Protecting infants exposed to HIV from severe infections
Official title: Developing Interventions for Protecting HIV-Exposed Uninfected Infants against Severe Infections
Funded at University of Colorado Denver · NIH-11007740 · Data updated 2026-11-12
This study is looking at why babies who are exposed to HIV but don’t have the virus themselves seem to get sicker more often than babies who aren't exposed, and it aims to find out how the bacteria in their guts and their immune systems play a role, so we can discover ways to help these babies stay healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 9, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $688,425 |
| NIH project number | 1R01HD116631-01 |
| Project ID | NIH-11007740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants who are HIV-exposed but uninfected, particularly those within the first year of life.
✕Less likely to help
Patients who are HIV-infected or those who are older than one year may not benefit from this research.
What this research studies
This research focuses on understanding why infants who are exposed to HIV but are uninfected (HEU) are at a higher risk for severe infections compared to those not exposed (HU). The study will investigate the role of gut microbiota and immune responses in these infants, aiming to identify specific bacteria and metabolites that contribute to immune dysfunction. By analyzing the immune and microbiome profiles of both groups over the first year of life, researchers hope to find dietary interventions that could improve health outcomes for HEU infants.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that significantly reduce the risk of severe infections in HIV-exposed uninfected infants.
How similar studies have gone: Previous research has shown promising results in understanding the microbiome's role in immune function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Weinberg, Adriana — University of Colorado Denver
- Study coordinator: Weinberg, Adriana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.