Protecting infants exposed to HIV from severe infections
Developing Interventions for Protecting HIV-Exposed Uninfected Infants against Severe Infections
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11007740
This study is looking at why babies who are exposed to HIV but don’t have the virus themselves seem to get sicker more often than babies who aren't exposed, and it aims to find out how the bacteria in their guts and their immune systems play a role, so we can discover ways to help these babies stay healthier.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11007740 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding why infants who are exposed to HIV but are uninfected (HEU) are at a higher risk for severe infections compared to those not exposed (HU). The study will investigate the role of gut microbiota and immune responses in these infants, aiming to identify specific bacteria and metabolites that contribute to immune dysfunction. By analyzing the immune and microbiome profiles of both groups over the first year of life, researchers hope to find dietary interventions that could improve health outcomes for HEU infants.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants who are HIV-exposed but uninfected, particularly those within the first year of life.
Not a fit: Patients who are HIV-infected or those who are older than one year may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that significantly reduce the risk of severe infections in HIV-exposed uninfected infants.
How similar studies have performed: Previous research has shown promising results in understanding the microbiome's role in immune function, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEINBERG, ADRIANA — UNIVERSITY OF COLORADO DENVER
- Study coordinator: WEINBERG, ADRIANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Airway infections