Protecting heart cell mitochondria to help heart failure
Synergistically Target Mitochondria for Heart Failure Treatment
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11112368
Combining ways to preserve mitochondrial energy and remove harmful mitochondrial oxygen molecules to help people with heart failure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11112368 on ClinicalTrials.gov |
What this research studies
Heart cells depend on tiny structures called mitochondria for energy, and in heart failure these mitochondria can lose their energy state and produce damaging oxygen molecules. This project aims to both keep mitochondrial membrane potential stable and clear excess mitochondrial reactive oxygen species at the same time. To accomplish that, researchers will create and use new tools to control mitochondria in living hearts and test the combined approach in animal models. If those experiments show improved heart function and structure, the researchers plan to move the findings toward treatments that could be tested in people.
Who could benefit from this research
Good fit: Adults with chronic heart failure, especially those with weakened heart muscle or evidence suggesting mitochondrial dysfunction, would be the main candidates for future trials based on this work.
Not a fit: People with acute, emergency heart conditions, heart problems unrelated to mitochondrial dysfunction, or those needing immediate lifesaving interventions are unlikely to benefit directly from this early-stage research.
Why it matters
Potential benefit: If successful, this approach could lead to new therapies that strengthen heart function and slow progression of heart failure.
How similar studies have performed: Prior antioxidant therapies showed promise in animal studies but largely failed in human trials, so combining membrane-stabilizing methods with ROS scavenging is a newer strategy that has limited prior success in people.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, LUFANG — OHIO STATE UNIVERSITY
- Study coordinator: ZHOU, LUFANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.