Protecting DNA in Reproductive Cells
A NOVEL PROCESS SAFEGUARDS GENOME INTEGRITY IN THE MAMMALIAN GERM LINE
This research explores a new way our bodies protect the DNA in reproductive cells from damage that could lead to serious health problems for future generations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-11086011 on NIH RePORTER |
What this research studies
Our DNA contains special repeating sections that can sometimes twist into a fragile shape called Z-DNA, which can cause breaks and large changes in our genetic code. If these changes happen in reproductive cells, they could be passed on to children. We found a protein called ZBTB43 that helps control this Z-DNA structure in reproductive cells, preventing these harmful breaks. This work uses advanced techniques with mouse models to understand how ZBTB43 works to keep our genetic information safe.
Who could benefit from this research
Good fit: This foundational research uses mouse models and does not involve direct patient participation at this time.
Not a fit: Patients seeking immediate treatment for existing conditions would not directly benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how to prevent genetic mutations in reproductive cells, potentially reducing the risk of inherited diseases in future generations.
How similar studies have performed: This research describes the discovery of a novel biological process, indicating a new and untested approach to safeguarding genome integrity.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Szabó, Piroska Edit — Van Andel Research Institute
- Study coordinator: Szabó, Piroska Edit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.