Protecting brain tissue after a stroke with natural compounds
Neuroprotective lipid mediators target penumbra in experimental ischemic stroke
['FUNDING_R01'] · LSU HEALTH SCIENCES CENTER · NIH-11132902
This research explores how natural compounds called elovanoids might protect brain cells from damage after an ischemic stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LSU HEALTH SCIENCES CENTER (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11132902 on ClinicalTrials.gov |
What this research studies
Ischemic stroke causes long-term disability, and new treatments are urgently needed to protect brain tissue. This project focuses on special natural compounds called elovanoids, which are made from certain fatty acids in the body. Researchers believe these compounds can help brain cells survive in the area around a stroke, known as the penumbra, preventing further damage. They are using advanced techniques to understand how these compounds work at a genetic level in different brain cells like neurons and astrocytes. The ultimate goal is to find new ways to promote cell survival rather than just reducing inflammation after a stroke.
Who could benefit from this research
Good fit: This foundational research is for patients interested in the development of new therapies for ischemic stroke, particularly those focused on protecting brain tissue.
Not a fit: Patients seeking immediate treatment options or direct clinical trial participation would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect brain tissue and improve recovery for people who have experienced an ischemic stroke.
How similar studies have performed: Preliminary data in animal models has shown promising results, with improved behavior and reduced brain damage after stroke using these compounds.
Where this research is happening
NEW ORLEANS, UNITED STATES
- LSU HEALTH SCIENCES CENTER — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAZAN, NICOLAS G. — LSU HEALTH SCIENCES CENTER
- Study coordinator: BAZAN, NICOLAS G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.