Protecting brain cells in Parkinson's disease through gut signaling
Official title: Neuroprotection by the GUCY2C gut-brain axis in Parkinson's disease
Funded at Thomas Jefferson University · NIH-10740951 · Data updated 2026-11-12
This study is looking at how a specific gut-brain connection might help protect brain cells in people with Parkinson's disease, with the hope of finding new ways to slow down the disease and improve treatments for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $429,000 |
| NIH project number | 1R21NS130388-01A1 |
| Project ID | NIH-10740951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing motor dysfunction or cognitive decline.
✕Less likely to help
Patients with Parkinson's disease who are in advanced stages of the disease or those with other neurodegenerative conditions may not benefit from this research.
What this research studies
This research investigates how the GUCY2C gut-brain axis may protect dopamine neurons from degeneration in Parkinson's disease. By understanding the role of this receptor in mitochondrial function and its connection to brain signaling, the study aims to develop new therapeutic strategies that could prevent the progression of the disease. The approach involves examining the effects of GUCY2C signaling on neuronal health and its potential to mitigate oxidative stress and cell death. Patients may benefit from insights that could lead to innovative treatments targeting the underlying causes of Parkinson's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of Parkinson's disease.
How similar studies have gone: Other research has shown promise in targeting gut-brain signaling pathways for neuroprotection, suggesting potential for success in this novel approach.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Waldman, Scott a — Thomas Jefferson University
- Study coordinator: Waldman, Scott a
Related research
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Gut-brain connections in Parkinson’s disease: how the gut and environment shape symptoms
A Mayo Clinic team is studying how gut problems, environmental factors, and genetics together influence Parkinson’s disease and its GI symptoms to find biomarkers and better understanding of the disease.
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Gut-brain communication in Parkinson’s disease for better symptoms and daily life
This project enrolls people with Parkinson’s disease and healthy controls to build a big registry and study how gut function, brain signals, sleep, and circadian rhythms relate to PD symptoms.
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Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression
A multi-year study will look at gut bacteria and related markers in people with Parkinson’s disease to understand how the gut-brain connection may influence symptoms and progression.
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Gut-Brain Axis in Parkinson’s Disease: biomarkers and procedures to track progression
A patient-focused program to study how gut health and the brain interact in Parkinson’s disease using biomarkers and clinical procedures.
-
Understanding posture and movement in Parkinson’s patients to reduce falls
A study using wearable sensors to track real-world balance and movement in people with Parkinson’s disease to help prevent falls.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.