Protecting brain cells and reducing inflammation in Alzheimer's disease
Mitigating neuroinflammation and enhancing neuronal integrity in Alzheimer's disease
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-11124076
This research explores how a natural protein called MG53 might help slow down Alzheimer's disease by shielding brain cells and calming inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-11124076 on ClinicalTrials.gov |
What this research studies
Alzheimer's disease involves ongoing brain inflammation and the buildup of harmful proteins. This project looks at MG53, a protein that helps repair cells and reduce inflammation, as a way to protect brain cells from damage. We are learning how MG53 can get into the brain and if it can lessen the effects of Alzheimer's. The goal is to find new ways to keep brain cells healthy and reduce inflammation, which could help slow the disease's progression.
Who could benefit from this research
Good fit: This foundational research is focused on understanding disease mechanisms and potential therapeutic targets for individuals with Alzheimer's disease.
Not a fit: Patients without Alzheimer's disease or related neurodegenerative conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect brain cells and reduce inflammation, potentially slowing the progression of Alzheimer's disease.
How similar studies have performed: Initial findings in animal models suggest MG53 has protective effects against brain injury and inflammation, indicating a promising, though still early, approach for Alzheimer's.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, JIANJIE — UNIVERSITY OF VIRGINIA
- Study coordinator: MA, JIANJIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Alzheimer disease dementia, Alzheimer syndrome