Prorenin receptor and diabetic eye disease
Pro/renin receptor-mediated signaling in pathogenesis of diabetic retinopathy
This project looks at how a protein called the prorenin receptor may drive eye damage in people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11160724 on NIH RePORTER |
What this research studies
From my point of view, researchers will compare samples from people with diabetic retinopathy to lab models to see how the prorenin receptor (PRR) causes inflammation and oxidative stress in the retina. They will measure prorenin and related molecules in eye fluid and use cell and animal experiments to trace PRR-linked pathways, including angiotensin II and connections to V-ATPase and Wnt signaling. The team will test whether blocking PRR-related signals reduces retinal damage in experimental models. Findings will be used to point to possible targets for future therapies to protect vision in diabetes.
Who could benefit from this research
Good fit: People with diabetes, especially those with early or established diabetic retinopathy or those willing to donate eye fluid or clinical samples, would be most relevant to this work.
Not a fit: People without diabetes or those whose vision loss is already irreversible are unlikely to benefit directly from this research.
Why it matters
Potential benefit: If successful, this work could point to new ways to prevent or slow vision loss from diabetic retinopathy.
How similar studies have performed: Prior laboratory and clinical observations link prorenin and PRR to retinal damage, but translating those findings into treatments is still novel and not yet proven in patients.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Li, Qiuhong — University of Florida
- Study coordinator: Li, Qiuhong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.