Promoting renewal of red blood cell precursors
Erythroid Self-Renewal
['FUNDING_R01'] · UNIVERSITY OF ROCHESTER · NIH-11138605
Testing ways to help immature red blood cell precursors keep multiplying so we can make more healthy red blood cells for people with anemia or blood disorders.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11138605 on ClinicalTrials.gov |
What this research studies
Researchers are studying how immature red blood cell precursors divide and renew themselves, using experiments in lab dishes and animal models. They focus on a gene called BMI1 and related pathways, including cholesterol-related genes, that seem to let these precursor cells expand for longer. Past work found that altering BMI1 can produce human cells that keep renewing in the lab, and the team is exploring the detailed mechanisms behind that effect. The goal is to learn how to safely produce large numbers of red blood cell precursors that could eventually help patients needing transfusions or treatments for anemia.
Who could benefit from this research
Good fit: People with anemia or other red blood cell disorders, as well as healthy blood donors willing to provide samples, would be relevant participants or sample sources for this research.
Not a fit: Patients with unrelated medical conditions or those needing immediate emergency care are unlikely to directly benefit from this laboratory-focused work in the short term.
Why it matters
Potential benefit: If successful, this work could enable new ways to grow large numbers of red blood cells for transfusions and lead to improved treatments for anemia.
How similar studies have performed: Early laboratory studies have shown BMI1 can expand human erythroid cells in vitro, but translating this into clinical therapies remains untested.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PALIS, JAMES — UNIVERSITY OF ROCHESTER
- Study coordinator: PALIS, JAMES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.