Prokaryotic Transcription Termination: how bacteria and archaea stop copying DNA
Official title: Prokaryotic Transcription Termination R37GM041376-R01GM041376 - Competitive Renewal Resubmission 1
Funded at Rutgers, the State Univ of N.j. · NIH-11352529 · Data updated 2026-11-12
A funded project aims to learn, at a molecular level, how bacteria and archaea stop reading DNA and how this process is controlled.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project start | December 1, 1988 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $536,460 |
| NIH project number | 5R01GM041376-38 |
| Project ID | NIH-11352529 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly; this is basic science in microorganisms.
✕Less likely to help
No direct patient involvement or benefit expected.
What this research studies
This grant supports advanced structural studies to reveal how transcription termination happens in bacteria like E. coli and in archaea like Thermococcus kodakarensis. Researchers will determine high-resolution structures of termination complexes and partners, using cryo-electron microscopy and other biochemical methods. By mapping the steps from pre-termination to post-termination, the work aims to uncover fundamental processes that control gene expression in microbes. The findings could illuminate targets for new antibacterial strategies and deepen our understanding of essential cellular biology.
Why it matters
Potential benefit: Better understanding of how microbes regulate gene expression could lead to novel antibacterial approaches and insights into basic biology.
How similar studies have gone: Recent structural biology work has begun to reveal some termination intermediates, but complete mechanistic pictures remain incomplete.
Where this research is happening
-
Rutgers, the State Univ of N.j.
Piscataway, United States Active
Researchers
- Principal investigator: Ebright, Richard H. — Rutgers, the State Univ of N.j.
- Study coordinator: Ebright, Richard H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.